Delays in adequate source control are associated with worsened outcomes. Infected or necrotic material must be drained or removed as part of the treatment plan in this setting. Source control is a key concept in the treatment of most surgically relevant infections. Outcomes in patients with sepsis are improved with an organized approach to therapy that includes rapid resuscitation, antibiotics, and source control. Sepsis is a clinical spectrum, ranging from sepsis (SIRS plus infection) to severe sepsis (organ dysfunction), to septic shock (hypotension requiring vasopressors). Sepsis is both the presence of infection and the host response to infection (systemic inflammatory response syndrome, SIRS).
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